Codeine and promethazine is a combination drugs utilized to take care of cold or allergy signs and symptoms like runny nose, sneezing, and cough.
Promethazine is undoubtedly an H1 receptor blocking agent. Together with its antihistaminic motion, it offers clinically useful sedative and antiemetic effects.
Almost all of the experiments, equally favourable and destructive, were restricted by little sample dimension, recall bias and absence of data with regards to dose and timing of publicity.
Drug interactions may possibly transform how your drugs do the job or increase your danger for serious Unwanted effects. This document isn't going to have all probable drug interactions.
Circumstances OF USE: The information During this databases is intended to supplement, not substitute for, the abilities and judgment of healthcare experts. The data is just not intended to address all attainable makes use of, Instructions, precautions, drug interactions or adverse outcomes, nor ought to it's construed to indicate that usage of a particular drug is Safe and sound, proper or helpful to suit your needs or anybody else.
A healthcare professional ought to be consulted just before taking any drug, modifying any diet plan or commencing or discontinuing any program of treatment.
Endocrine/Metabolic: Circumstances of serotonin syndrome, a perhaps daily life-threatening problem, have already been reported during concomitant usage of opioids with serotonergic medications.
If you take promethazine and codeine frequently, have a skipped dose the moment you think about it. Whether it is near to the time for your personal future dose, skip the missed dose and return to your usual time.
Retail outlet at area temperature. Protect from gentle. Retail outlet in the dry location. Will not keep in a very lavatory. Maintain all prescription drugs in a secure area. Hold all medicines out from the access of youngsters and Animals. Throw absent unused or expired prescription drugs.
Absorption Codeine is absorbed with the gastrointestinal tract with utmost plasma concentration taking place 60 minutes publish administration. The existence of a superior-Fats, large-calorie food didn't drastically influence the PK of codeine.
Cytochrome P450 2D6 is the major enzyme chargeable for conversion of codeine to morphine and P450 3A4 is the key enzyme mediating conversion of codeine to norcodeine. Morphine and norcodeine are further metabolized by conjugation with get more info glucuronic acid. The glucuronide metabolites of morphine are morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G). Morphine and its M6 glucuronide conjugate are pharmacologically Energetic. Whether or not C6G has pharmacological exercise is unidentified. Norcodeine and M3 glucuronide conjugate of morphine are frequently not regarded as pharmacologically active.
Retail store at area temperature away from dampness, heat, and light-weight. Keep track of your medication. Try to be conscious if any one is using your drugs improperly or without a prescription.
Just before using this medication, Girls of childbearing age ought to communicate with their health practitioner(s) with regards to the hazards and Rewards. Tell your health practitioner If you're pregnant or think you could be Expecting. For the duration of pregnancy, this medication isn't encouraged. It might a bit improve the danger of beginning defects if utilised over the to start with two months of pregnancy. Also, using it for some time or in large doses near the anticipated shipping and delivery day may hurt the unborn toddler.
The concomitant use of anticholinergic medications with Promethazine with Codeine Oral Option may perhaps improve threat of urinary retention and/or serious constipation, which may cause paralytic ileus [see Warnings and Safeguards ( five.eleven) ]. Watch people for indications of urinary retention or minimized gastric motility when Promethazine with Codeine Oral Alternative is applied concomitantly with anticholinergic medicine.